Structural Studies on Heparan Sulphates
نویسندگان
چکیده
منابع مشابه
Glycomics Approaches for the Bioassay and Structural Analysis of Heparin/Heparan Sulphates
The glycosaminoglycan heparan sulphate (HS) has a heterogeneous structure; evidence shows that specific structures may be responsible for specific functions in biological processes such as blood coagulation and regulation of growth factor signalling. This review summarises the different experimental tools and methods developed to provide more rapid methods for studying the structure and functio...
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We analysed the distribution, structural characteristics, antithrombin-III-binding properties and anticoagulant activities of heparins and heparan sulphates isolated from the tissues of a wide range of vertebrates. Heparin has a curiously limited distribution, since it was absent from lower aquatic vertebrate species, present in only certain organs such as intestine in many higher vertebrates, ...
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This study presents a comparison of heparan sulphate chains isolated from various porcine and bovine tissues. 1H-NMR spectroscopy (500 MHz) was applied for structural and compositional studies on intact heparan sulphate chains. After enzymic digestion of heparan sulphate using heparin lyase I (EC 4.2.2.7) II and III (EC 4.2.2.8), the compositions of unsaturated disaccharides obtained were deter...
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Hepatocyte growth factor/scatter factor (HGF/SF) is a 90 kDa paracrine factor synthesised by mesenchymal cells. In the extracellular milieu it is proteolytically clipped, yielding a disulphide-linked heterodimer (60 kDa α chain and 30 kDa β chain). The mature processed molecule is biologically active upon epithelial and endothelial cells, and also haemopoietic progenitor cells, and appears to h...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 2005
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1980.tb05997.x